化工进展
Home |  |  |  |  |  |  |  | Chinese
Chemical Industry and Engineering Progree
Current Issue | Next Issue | Archive | Adv Search Previous Articles  |  Next Articles  
Molecularly imprinted polymer hydrogel as 5-FU controlled release carrier
KAN Wentao1,LI Xin2,LUO Shunzhong1,HU Rui1
1Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang 621900,Sichuan,China; 2Department of Chemistry,Harbin Institute of Technology,Harbin 150001,Heilongjiang,China
 Download: PDF (0 KB)   HTML (1 KB)   Export: BibTeX | EndNote (RIS)      Supporting Info
Abstract 5-fluorouracil as template drug,2-hydroxyethylmetacrylate as backbone monomer,methacrylic acid as functional monomer,ethyleneglycol dimethacrylate as crosslinker and 2,2’-azoisobutyronitrile as initiator were used to synthesize molecularly imprinted polymer hydrogels,which were characterized with SEM,FT-IR,and DSC. The results indicated that the hydrogel surface was poreless and smooth,and in hydrogels the template drug of 5-fluorouracil interacted with monomers into solid solutions through hydrogen bonds and unreacted monomers no longer existed. Swelling tests of imprinted hydrogels showed that swelling capacity increased with the amount of 5-fluorouracil during synthesis,and swelling ability as well as swelling speed increased with increasing pH in the system. Meanwhile tests of drug loading capacity showed that the imprinted hydrogels both performed better than the non-imprinted one and MIP(functional monomer-template molar ratio 8∶1) performed better than MIP(functional monomer-template molar ratio 4∶1) with loading capacity amounting to 0.0914 mg/g.Tests on drug release behavior of the hydrogels in simulated biological fluids indicated that all the imprinted hydrogels controlled drug release better than the non-imprinting one,and hydrogels with functional monomer-template molar ratio 8∶1 exhibited the best to control the 5-fluorouracil release process. Meanwhile,release media with a high pH was unfavorable to controlled release of the imprinted hydrogel.
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
KAN Wentao1
LI Xin2
LUO Shunzhong1
HU Rui1
Key wordscontrolled release of drug   molecular imprinting   hydrogel   5-fluorouracil   carrier     
Cite this article:   
KAN Wentao1,LI Xin2,LUO Shunzhong1 et al. Molecularly imprinted polymer hydrogel as 5-FU controlled release carrier[J]. Chemical Industry and Engineering Progree, 2013, 32(03): 627-633.
URL:  
http://www.hgjz.com.cn/EN/     or     http://www.hgjz.com.cn/EN/Y2013/V32/I03/627
 
No references of article
[1] QIANG Taotao,ZHANG Guoguo,WANG Xuechuan. Research developments on amphiphilic hyperbranched polymers[J]. Chemical Industry and Engineering Progree, 2013, 32(03): 666-670.
[2] TAN Xianzhou 1,LI Hui 1,2,LU Cuimei 2,LI Gui 1. Preparation and adsorption behavior of chlorogenic acid imprinted polymer by using nano-TiO2 as sacrificial support material[J]. Chemical Industry and Engineering Progree, 2013, 32(02): 388-393.
[3] MEI Jiajun, ZHANG Changqing, LIU Rongming, MA Jiangfeng, CHEN Kequan, JIANG Min. Succinic acid production with immobilized cells of Escherichia coli on modified carrier[J]. Chemical Industry and Engineering Progree, 2013, 32(01): 161-165.
[4] PENG Fen,LIU Yuan,HUANG Wei. Effect of supports on Co-Cu catalyst performance for step-wise conversion of CH4 and syngas[J]. CIESC Journal, 2012, 63(S1): 159-164.
[5] WANG Luyi,SHAN Guorong. Influence of poly(ethylene oxide)on structure and properties of PAMPS/PAM double network hydrogels[J]. CIESC Journal, 2012, 63(8): 2642-2647.
[6] HU Yuanchen, ZHANG Xinsheng, CUI Shuang, REN Wenfeng, YU Liangying, HU Xuejiao. Bio-mimic transpiration cooling using temperature-sensitive hydrogel[J]. CIESC Journal, 2012, 63(7): 2025-2032.
[7] ZHOU Qi,LI Wei,SHI Yuli,JIANG Binbo,WANG Jingdai,YANG Yongrong. Blending properties of polyethylene blends obtained by hybrid catalyst immobilizing on composite support[J]. CIESC Journal, 2012, 63(6): 1735-1741.
[8] DUAN Lihong1,JIN Bei2,GAO Lijun2,FENG Zongcai3. Genipin-crosslinked soybean protein/chitosan hydrogels for controlled release[J]. CIESC Journal, 2012, 63(3): 962-969.
[9] LIU Zongkuan1,ZHANG Lei1,JIANG Jian2,BIAN Cheng2. Advances in coal tar hydro-refining and hydro-cracking catalysts[J]. Chemical Industry and Engineering Progree, 2012, 31(12): 2672-2677.
[10] TIAN Ting,LU Jinren,BAO Mutai,WANG Kaikai. Technological status and research advances in oily wastewater treatment of three-phase biological fluidized bed reactor[J]. Chemical Industry and Engineering Progree, 2012, 31(12): 2775-2779.
[11] TANG Lili, HE Daohang, GUAN Fuyi. Progress of peptide based self-assembled nanomaterials for drug and gene delivery[J]. CIESC Journal, 2012, 63(11): 3383-3392.
[12] LI Fan,ZHANG Jinlong,YIN Yuji. Research progress of high mechanical strength hydrogels for biomedical application[J]. Chemical Industry and Engineering Progree, 2012, 31(11): 2511-2519.
[13] SONG Yuning,XIN Meihua,LI Mingchun,ZHOU Shengquan. Synthesis and characterization of folate-conjugated quaternized chitosan as a gene delivery vector[J]. Chemical Industry and Engineering Progree, 2012, 31(11): 2542-2547.
[14] LIU Fenrong1,GUO Huiqing2,HU Ruisheng1,HE Shuying1,HU Haoquan3. A study on the loading behavior of sulfur containing compounds on the different carriers and sulfur release behavior during combustion process[J]. Chemical Industry and Engineering Progree, 2012, 31(11): 2570-2573.
[15] LIN Tianming,JING Guohua. Research and application progress of magnetically stabilized fluidized bed[J]. Chemical Industry and Engineering Progree, 2012, 31(09): 1885-1890.
CopyRight © 2012 Editor By SPACECRAFT RECOVERY & REMOTE SENSING
Support By Beijin Magtech