分子筛催化二甲苯甲醇烷基化制备偏三甲苯

陈旭; 任欢; 孙道来; 薛伟; 吕建华

doi:10.16085/j.issn.1000-6613.2026-0333

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分子筛催化二甲苯甲醇烷基化制备偏三甲苯

工业催化 | 更新时间：2026-04-30

- 分子筛催化二甲苯甲醇烷基化制备偏三甲苯
- Synthesis of 1,2,4-trimethylbenzene via xylene alkylation with methanol catalyzed by zeolite catalysts
- 化工进展 2026年
- 作者机构：
  
  河北工业大学化工学院，天津300130
- 作者简介：
  
  陈旭（2000—），女硕士研究生，研究方向为工业催化。E-mail：13614524776@163.com。
  孙道来，副教授，博士生导师，研究方向为工业催化。E-mail：sundaolai@hebut.edu.cn。
- 基金信息：
- DOI：10.16085/j.issn.1000-6613.2026-0333
  中图分类号： TQ241
- 收稿：2026-03-06，
  
  修回：2026-04-10，
  
  录用：2026-04-13，
- 稿件说明：
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陈旭, 任欢, 孙道来, 等. 分子筛催化二甲苯甲醇烷基化制备偏三甲苯[J/OL]. 化工进展, 2026.

CHEN Xu, REN Huan, SUN Daolai, et al. Synthesis of 1,2,4-trimethylbenzene via xylene alkylation with methanol catalyzed by zeolite catalysts[J/OL]. Chemical Industry and Engineering Progress, 2026.
陈旭, 任欢, 孙道来, 等. 分子筛催化二甲苯甲醇烷基化制备偏三甲苯[J/OL]. 化工进展, 2026. DOI： 10.16085/j.issn.1000-6613.2026-0333.

CHEN Xu, REN Huan, SUN Daolai, et al. Synthesis of 1,2,4-trimethylbenzene via xylene alkylation with methanol catalyzed by zeolite catalysts[J/OL]. Chemical Industry and Engineering Progress, 2026. DOI： 10.16085/j.issn.1000-6613.2026-0333.

摘要

偏三甲苯（1

4-TMB）作为重要有机化工原料，在化学工业中有着重要的用途。本研究开发了一种以二甲苯（Xyl）和甲醇为原料，以分子筛为催化剂合成1

4-TMB的工艺。首先，以间二甲苯（MX）为原料，考察了H-Mordenite、H-USY、HY、Hβ、MCM-41和HZSM-5等6种分子筛的催化效果，发现硅铝比为50的HZSM-5具有较高的催化活性，并对上述催化剂进行了表征，探讨了构效关系。在此基础上，研究了反应温度、反应时间、质量空速、原料比例等对反应的影响。在反应温度为250℃、质量空速0.45h

-1

，MX与甲醇进料摩尔比为1:2的条件下，MX转化率为22.8%，1

4-TMB的选择性达到69.5%。HZSM-5对其他种类Xyl也具有较好的催化活性，以混合Xyl（OX:MX:PX=1:1:1）为原料，Xyl的转化率和1

4-TMB的选择性可以分别达到14.0%和69.3%。

Abstract

4-TMB is an important organic chemical raw material with significant applications in chemical industry. This study developed a process for the synthesis of 1

4-TMB using xylene and methanol as feedstocks over zeolite catalysts. Initially

the catalytic performance of six zeolites

namely H-Mordenite

H-USY

Hβ

MCM-41

and HZSM-5

was evaluated using m-xylene (MX) as the reactant. HZSM-5 with a SiO

/Al

ratio of 50 exhibited the highest catalytic activity. These catalysts were characterized to elucidate the structure-activity rel

ationship. Subsequently

the effects of reaction temperature

reaction time

weight hourly space velocity

and feedstock ratio on the reaction were investigated. Under the optimized conditions of 250℃

weight hourly space velocity of 0.45h⁻¹

and MX to methanol molar ratio of 1:2

the conversion of MX reached 22.8%

with a selectivity of 69.5% for 1

4-TMB. HZSM-5 also demonstrated good catalytic activity toward other xylene isomers. When mixed xylenes(OX:MX:PX=1:1;1) were used as the feedstock

the xylene conversion and 1

4-TMB selectivity were 14.0% and 69.3%

respectively.

关键词

Keywords

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